[Interdisciplinary S2k guidelines on the diagnosis and treatment of vaginal carcinoma and its precursors-recommendations on surgical pathology for histopathological workup, diagnostics, and reporting]. / S2k-Leitlinie Diagnostik und Therapie des Vaginalkarzinoms und seiner Vorstufen Anforderungen an die Pathologie.
Pathologe
; 42(1): 116-124, 2021 Feb.
Article
em De
| MEDLINE
| ID: mdl-33346872
ABSTRACT
Primary vaginal carcinoma is rare. There are two pathogenetic pathways, one associated with HPV high-risk infection and another one with inactivation of p53. Vaginal Paget's disease is rare and mostly associated with vulvar disease or represents intravaginal spread of associated locoregional cancer. Diagnostic vaginal biopsies should be examined by step sections on H&E. Sentinel lymph nodes should be processed completely using ultrastaging. Morphology-based prognostic factors with good clinical evidence are tumour stage and lymph node status. Molecular markers are not currently relevant for treatment decision and prognosis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Patologia Cirúrgica
/
Neoplasias Vaginais
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Neoplasias Vulvares
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Carcinoma in Situ
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
De
Revista:
Pathologe
Ano de publicação:
2021
Tipo de documento:
Article