The Jekyll and Hyde of Senescence in Cancer: TIMP1 Controls the Switch from Tumor-Controlling to Tumor-Promoting Senescence.

Da Silva-Álvarez, Sabela; Collado, Manuel

Da Silva-Álvarez, Sabela; Collado, Manuel.

Afiliação

Da Silva-Álvarez S; Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), E15706 Santiago de Compostela, Spain.
Collado M; Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), E15706 Santiago de Compostela, Spain. Electronic address: manuel.collado.rodriguez@sergas.es.

Cancer Cell ; 39(1): 13-15, 2021 01 11.

Article em En | MEDLINE | ID: mdl-33357453

ABSTRACT

ABSTRACT

Cellular senescence is a response with two faces in cancer it restricts tumor proliferation, but it can also promote cancer progression and metastasis. In this issue of Cancer Cell, Guccini et al. uncover the role of TIMP1 in prostate cancer allowing a switch from tumor-controlling to tumor-promoting senescence.

Assuntos

Neoplasias da Próstata; Senescência Celular/genética; Humanos; Masculino; Neoplasias da Próstata/genética; Inibidor Tecidual de Metaloproteinase-1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata Limite: Humans / Male Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Espanha

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