Time between milestone events in the Alzheimer's disease amyloid cascade.
Neuroimage
; 227: 117676, 2021 02 15.
Article
em En
| MEDLINE
| ID: mdl-33359337
ABSTRACT
OBJECTIVE:
Estimate the time-course of the spread of key pathological markers and the onset of cognitive dysfunction in Alzheimer's disease.METHODS:
In a cohort of 335 older adults, ranging in cognitive functioning, we estimated the time of initial changes of Aß, tau, and decreases in cognition with respect to the time of Aß-positivity.RESULTS:
Small effect sizes of change in CSF Aß42 and regional Aß PET were estimated to occur several decades before Aß-positivity. Increases in CSF tau occurred 7-8 years before Aß-positivity. Temporoparietal tau PET showed increases 4-5 years before Aß-positivity. Subtle cognitive dysfunction was observed 4-6 years before Aß-positivity.CONCLUSIONS:
Increases in tau and cognitive dysfunction occur years before commonly used thresholds for Aß-positivity. Explicit estimates of the time for these events provide a clearer picture of the time-course of the amyloid cascade and identify potential windows for specific treatments.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
/
Proteínas tau
/
Progressão da Doença
/
Doença de Alzheimer
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neuroimage
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2021
Tipo de documento:
Article