Association Between Dietary Fish and PUFA Intake in Midlife and Dementia in Later Life: The JPHC Saku Mental Health Study.
J Alzheimers Dis
; 79(3): 1091-1104, 2021.
Article
em En
| MEDLINE
| ID: mdl-33386799
ABSTRACT
BACKGROUND:
The relationship between midlife dietary habits and risk of dementia remains unclear.OBJECTIVE:
To investigate the association between dietary fish and n-3 polyunsaturated fatty acid (PUFA) consumption in midlife and risk of dementia in later life.METHODS:
This population-based cohort study assessed food frequency (average intake in 1995 and 2000) and cognition (2014-2015) in 1,127 participants (aged 45-64 in 1995). We used logistic regression analyses to calculate odds ratios (ORs) for dementia and mild cognitive impairment (MCI) diagnoses for consumption quartiles of fish, PUFA-rich fish, total n-3 PUFAs, total n-6 PUFAs, types of PUFAs, and n-3/n-6 PUFA ratio. Estimated ORs were adjusted for age; sex; education; smoking status; alcohol consumption frequency; physical activity; histories of cancer, myocardial infarction, and diabetes mellitus; and depression.RESULTS:
Significantly reduced risks of dementia over non-dementia (MCI plus cognitively normal) were observed in the second (ORâ=â0.43 (95% CIâ=â0.20-0.93)), third (ORâ=â0.22 (95% CIâ=â0.09-0.54)), and highest quartiles (ORâ=â0.39 (95% CIâ=â0.18-0.86)) for fish; the third (ORâ=â0.39 (95% CIâ=â0.16-0.92)) and highest quartiles (ORâ=â0.44 (95% CIâ=â0.19-0.98)) for eicosapentaenoic acid (EPA); the second (ORâ=â0.39 (95% CIâ=â0.18-0.84)), third (ORâ=â0.30 (95% CIâ=â0.13-0.70)), and highest quartiles (ORâ=â0.28 (95% CIâ=â0.12-0.66)) for docosahexaenoic acid (DHA); and the third (ORâ=â0.36 (95% CIâ=â0.16-0.85)) and highest quartiles (ORâ=â0.42 (95% CIâ=â0.19-0.95)) for docosapentaenoic acid (DPA).CONCLUSION:
High intake of fish in midlife might aid in preventing dementia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Ômega-3
/
Demência
/
Comportamento Alimentar
/
Peixes
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Alzheimers Dis
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão