The Efficacy and Safety of Additional Anti-HER2-Targeting Drugs in the Treatment of HER2-Positive Advanced Breast Cancer: A Meta-Analysis.
Anticancer Agents Med Chem
; 21(14): 1931-1940, 2021.
Article
em En
| MEDLINE
| ID: mdl-33390124
ABSTRACT
BACKGROUND:
HER2-positive breast cancer patients account for one-fifth of the total breast cancer population. Besides, more anti-HER2-targeting drugs have appeared clinically.OBJECTIVE:
This study aimed to analyze the efficacy and safety of additional anti-HER2 (Human Epidermal growth Factor Receptor 2)-targeting drugs in the treatment of HER2-positive advanced breast cancers.METHODS:
The following databases were searched for published articles containing data on the efficacy and safety of additional anti-HER2-targeting drugs in HER2-positive advanced breast cancer from the time of their inception until December 2019 PubMed, Web of Science, EBSCO, and Cochrane library. The primary outcomes were Progression-Free Survival (PFS) and Overall Survival (OS).RESULTS:
The additional anti-HER2-targeting drugs significantly improved the PFS (HR 0.66, p<0.001) and OS (HR 0.77, p<0.001) of HER2-positive advanced breast cancer patients. Regarding drug types, lapatinib was the most effective (HR 0.53, 95% Cl 0.39-0.67, p<0.001), followed by pertuzumab (HR 0.72, 95% Cl 0.55-0.89, p=0.001). Trastuzumab was the least beneficial (HR 0.87, 95% Cl 0.31-1.44, p=0.594). Concerning treatment regimen, first-line treatment (HR 0.67, 95% Cl 0.52-0.82, p<0.001) was more effective than non-first-line treatment (HR 0.82, 95% Cl 0.71-0.94, p=0.004). The main Adverse Events (AEs) observed were diarrhea and decreased ejection fraction.CONCLUSION:
Additional anti-HER2-targeting drugs can improve long-term prognosis in HER2-positive advanced breast cancers. Besides, they are associated with fewer AEs and are tolerable. Lapatinib is the most effective drug, followed by pertuzumab, whereas trastuzumab is the least effective. Concerning treatment, we recommend the use of anti-HER2-targeting drugs in first-line therapy of HER2-positive advanced breast cancers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Receptor ErbB-2
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Female
/
Humans
Idioma:
En
Revista:
Anticancer Agents Med Chem
Assunto da revista:
ANTINEOPLASICOS
/
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China