Effects of hypoxia-inducible factor-1α and hypoxia-inducible factor-2α overexpression on hepatocellular carcinoma survival: A systematic review with meta-analysis.
J Gastroenterol Hepatol
; 36(6): 1487-1496, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33393670
ABSTRACT
BACKGROUND AND AIM:
The role of hypoxia-inducible factor-1α (HIF-1α) and hypoxia-inducible factor-2α (HIF-2α) has been implicated in the clinical prognosis of hepatocellular carcinoma (HCC), but the results remain controversial. We aim to investigate the association of HIF-1α and HIF-2α overexpression with the prognosis and clinicopathological features of HCC.METHODS:
A systematic search was conducted in PubMed, Embase, Scopus, Web of Science, and Cochrane Library until June 20, 2020. Meta-analysis was conducted to generate combined HRs with 95% confidence intervals (CI) for overall survival (OS) and disease-free survival (DFS). Odds ratios (ORs) with 95% CI were also derived by fixed or random effect model.RESULTS:
Twenty-two studies involving 3238 patients were included. Combined data suggested that overexpression of HIF-1α in HCC was not only correlated with poorer OS [HR = 1.75 (95% CI 1.53-2.00)] and DFS [HR = 1.64 (95% CI 1.34-2.00)] but was also positively associated with vascular invasion [OR = 1.83 (95% CI 1.36-2.48)], tumor size [OR = 1.36 (95% CI 1.12-1.66)], and tumor number [1.74 (95% CI 1.34-2.25)]. In contrast, HIF-2α overexpression was not associated with the prognosis and clinicopathological features of HCC.CONCLUSION:
Our data provided compelling evidence of a worse prognosis of HCC in HIF-1α overexpression patients but not HIF-2α overexpression ones.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Carcinoma Hepatocelular
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
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Subunidade alfa do Fator 1 Induzível por Hipóxia
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Neoplasias Hepáticas
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Gastroenterol Hepatol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China