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Delaying the final cut: A close encounter of checkpoint kinases at the midbody.
J Cell Biol ; 220(2)2021 02 01.
Article em En | MEDLINE | ID: mdl-33404606
How chromatin bridges are relayed to the chromosomal passenger complex (CPC) during mammalian cell division is unknown. In this issue, Petsalaki and Zachos (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202008029) show that the DNA damage checkpoint kinases ATM and Chk2 signal to the CPC to associate with a pool of cytoskeletal regulators, MKLP2-Cep55, in the midbody center and to delay abscission.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinese / Fuso Acromático Limite: Animals / Humans Idioma: En Revista: J Cell Biol Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinese / Fuso Acromático Limite: Animals / Humans Idioma: En Revista: J Cell Biol Ano de publicação: 2021 Tipo de documento: Article