Antenatal Steroids and Acute Kidney Injury in Preterm Infants.
Am J Perinatol
; 39(12): 1334-1340, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-33406538
ABSTRACT
OBJECTIVE:
The aim of this study was to identify the effects of antenatal steroids (ANS) on acute kidney injury (AKI) in very low birth weight (VLBW) preterm infants. STUDYDESIGN:
We performed a retrospective cohort study of VLBW infants admitted to a tertiary-care neonatal intensive care unit between January 2016 and June 2019. Infants were divided into no ANS, partial ANS, and complete ANS groups. Serum creatinine (SCr) levels and rates of AKI during the first 2 weeks of life were compared.RESULTS:
During the study period, 335 infants met our inclusion criteria. Among no, partial, and complete ANS groups, there were significant differences in rates of stages 2 and 3 AKI (17, 11, and 6%, respectively). Logistic regression analysis revealed that complete ANS course was associated with lower rates of AKI (odds ratio [OR] = 0.41 95% confidence interval [CI] 0.20-0.83) and stages 2 and 3 AKI (OR = 0.205 95% CI 0.075-0.563) compared with no ANS. Infants in complete ANS group had significantly lower SCr at 72 hours of life and at discharge, SCr peak was compared with infants in no ANS group.CONCLUSION:
In VLBW infants, complete ANS exposure may be associated with improved renal function and decreased risk for AKI compared with no ANS. KEY POINTS · The effects of antenatal steroid treatment on renal function in preterm infants are not clear.. · A complete course of antenatal steroid decreases the risk for acute kidney injury in preterm infants.. · Infants who are not exposed to antenatal steroids need closer observation of their renal function..
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Injúria Renal Aguda
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Infant
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Am J Perinatol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Turquia