Menstrual, reproductive and hormonal factors and thyroid cancer: a hospital-based case-control study in China.
BMC Womens Health
; 21(1): 13, 2021 01 06.
Article
em En
| MEDLINE
| ID: mdl-33407401
ABSTRACT
BACKGROUND:
There have been considerable studies on the effects of reproductive factors on thyroid cancer risk, while findings are inconsistent. In this analysis, we aimed to investigate the associations between menstrual, reproductive and hormonal factors with thyroid cancer occurrence in a population of Chinese women.METHODS:
Using data from a 11 matched case-control study performed between 2015 and 2017 in Zhejiang Province of China, a second analysis of 2261 pairs of female subjects was conducted. The possible effects for thyroid cancer were evaluated in logistic regression models by odds ratios (ORs) with 95% confidence intervals (CIs).RESULTS:
Later age at first pregnancy (for > 25 vs. ⦠20 years, OR 0.47, 95% CI 0.23-0.96) and longer duration of breast feeding (for 6-12 vs. ⦠6 months, OR 0.49, 95% CI 0.24-0.98) were significantly associated with decreased occurrence of thyroid cancer, while no trend was observed. Stratified by age at enrollment, only the association with duration of breast feeding remained significant, but limited to younger women (⦠50 years).CONCLUSIONS:
Our results suggested that women with later age at first pregnancy or longer breast feeding duration were less likely to have thyroid cancer. These findings supported an influence role of reproductive factors in thyroid cancer risk.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Neoplasias da Glândula Tireoide
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
BMC Womens Health
Assunto da revista:
SAUDE DA MULHER
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China