Epigenetic regulator Stuxnet modulates octopamine effect on sleep through a Stuxnet-Polycomb-Octß2R cascade.
EMBO Rep
; 22(2): e47910, 2021 02 03.
Article
em En
| MEDLINE
| ID: mdl-33410264
ABSTRACT
Sleep homeostasis is crucial for sleep regulation. The role of epigenetic regulation in sleep homeostasis is unestablished. Previous studies showed that octopamine is important for sleep homeostasis. However, the regulatory mechanism of octopamine reception in sleep is unknown. In this study, we identify an epigenetic regulatory cascade (Stuxnet-Polycomb-Octß2R) that modulates the octopamine receptor in Drosophila. We demonstrate that stuxnet positively regulates Octß2R through repression of Polycomb in the ellipsoid body of the adult fly brain and that Octß2R is one of the major receptors mediating octopamine function in sleep homeostasis. In response to octopamine, Octß2R transcription is inhibited as a result of stuxnet downregulation. This feedback through the Stuxnet-Polycomb-Octß2R cascade is crucial for sleep homeostasis regulation. This study demonstrates a Stuxnet-Polycomb-Octß2R-mediated epigenetic regulatory mechanism for octopamine reception, thus providing an example of epigenetic regulation of sleep homeostasis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Octopamina
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Proteínas de Drosophila
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Epigênese Genética
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Drosophila melanogaster
Limite:
Animals
Idioma:
En
Revista:
EMBO Rep
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China