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Phosphine modification of proline-glycine-proline tripeptide and study of its neuroprotective properties.
Alexey, Vinyukov V; Maxim, Dmitriev E; Lyudmila, Andreeva A; Alexey, Ustyugov A; Valery, Shevchenko P; Kristina, Sidoruk N; Boris, Lednev V; Vladimir, Freyman M; Yuriy, Dobrovolskiy A; Valery, Ragulin V; Nikolay, Myasoedov F.
Afiliação
  • Alexey VV; Laboratory of Superionics, Institute of Problems of Chemical Physics of RAS, Academician Semenov Avenue 1, Chernogolovka, Moscow Region, 142432, Russian Federation; Laboratory of Organophosphorous Compounds, Institute of Physiologically Active Compounds, Severniy pr. 1, Chernogolovka, Moscow Region,
  • Maxim DE; Laboratory of Organophosphorous Compounds, Institute of Physiologically Active Compounds, Severniy pr. 1, Chernogolovka, Moscow Region, 142432, Russian Federation.
  • Lyudmila AA; Department of Regulatory Peptides, Institute of Molecular Genetics, Kurchatov Square 2, Moscow, 123182, Russian Federation.
  • Alexey UA; Biological Testing Laboratory, Institute of Physiologically Active Compounds, Severniy pr. 1, Chernogolovka, Moscow Region, 142432, Russian Federation.
  • Valery SP; Department of Regulatory Peptides, Institute of Molecular Genetics, Kurchatov Square 2, Moscow, 123182, Russian Federation.
  • Kristina SN; Laboratory of Superionics, Institute of Problems of Chemical Physics of RAS, Academician Semenov Avenue 1, Chernogolovka, Moscow Region, 142432, Russian Federation.
  • Boris LV; Information Department, Institute of Physiologically Active Compounds, Severniy pr. 1, Chernogolovka, Moscow Region, 142432, Russian Federation.
  • Vladimir FM; Laboratory of Superionics, Institute of Problems of Chemical Physics of RAS, Academician Semenov Avenue 1, Chernogolovka, Moscow Region, 142432, Russian Federation.
  • Yuriy DA; Laboratory of Superionics, Institute of Problems of Chemical Physics of RAS, Academician Semenov Avenue 1, Chernogolovka, Moscow Region, 142432, Russian Federation.
  • Valery RV; Laboratory of Organophosphorous Compounds, Institute of Physiologically Active Compounds, Severniy pr. 1, Chernogolovka, Moscow Region, 142432, Russian Federation.
  • Nikolay MF; Department of Regulatory Peptides, Institute of Molecular Genetics, Kurchatov Square 2, Moscow, 123182, Russian Federation.
Biochem Biophys Res Commun ; 539: 15-19, 2021 02 05.
Article em En | MEDLINE | ID: mdl-33412416
BACKGROUND: Treatment of neurodegenerative diseases, such as Parkinson's disease, Huntington's chorea, Alzheimer's disease, is one of the priority directions in modern medicine. Thus, search and production of new physiologically active substances for the treatment of neurodegenerative disorders is one of the most important tasks for organic chemistry. The approach based on the replacement of a peptide bond in a peptide molecule with a structural isostere, non-hydrolyzable methylene phosphoryl fragment makes it possible to increase the metabolic stability of peptide molecules to the destructive action of peptidases. METHODS: This work is devoted to the approbation of a new synthetic approach to the production of physiologically active substances in a series of peptide-type compounds with activity by replacing the peptide bond with isosteric methylene-phosphoryl fragment with the preservation of the original amino acid sequence. RESULTS: A phosphine analog of the known physiologically active tripeptide proline-glycine-proline was obtained, cytotoxicity and neuroprotective properties of the initial tripeptide and its phosphine analog were studied. CONCLUSION: Preliminary biological tests have shown that the obtained phosphine analog of the proline-glycine-proline tripeptide is involved in modulating the formation of sediments in the cellular system of proteinopathy, which may indicate their potential antiaggregatory properties.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Fosfinas / Prolina / Fármacos Neuroprotetores / Doenças Neurodegenerativas / Agregação Patológica de Proteínas Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Fosfinas / Prolina / Fármacos Neuroprotetores / Doenças Neurodegenerativas / Agregação Patológica de Proteínas Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2021 Tipo de documento: Article