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Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition.
Sahin, Zafer; Biltekin, Sevde Nur; Yurttas, Leyla; Berk, Barkin; Özhan, Yagmur; Sipahi, Hande; Gao, Zhan-Guo; Jacobson, Kenneth A; Demirayak, Seref.
Afiliação
  • Sahin Z; Istanbul Medipol University, School of Pharmacy, Department of Pharmaceutical Chemistry, Istanbul, Turkey. Electronic address: zsahin@medipol.edu.tr.
  • Biltekin SN; Istanbul Medipol University, School of Pharmacy, Department of Pharmaceutical Chemistry, Istanbul, Turkey.
  • Yurttas L; Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eskisehir, Turkey.
  • Berk B; Istanbul Medipol University, School of Pharmacy, Department of Pharmaceutical Chemistry, Istanbul, Turkey.
  • Özhan Y; Yeditepe University, Faculty of Pharmacy, Department of Toxicology, Istanbul, Turkey.
  • Sipahi H; Yeditepe University, Faculty of Pharmacy, Department of Toxicology, Istanbul, Turkey.
  • Gao ZG; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, USA.
  • Jacobson KA; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, USA.
  • Demirayak S; Istanbul Medipol University, School of Pharmacy, Department of Pharmaceutical Chemistry, Istanbul, Turkey.
Eur J Med Chem ; 212: 113125, 2021 Feb 15.
Article em En | MEDLINE | ID: mdl-33422981
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiouracila / Receptores Purinérgicos P1 / Glioblastoma / Citosina / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Inibidores da Fosfodiesterase 4 / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiouracila / Receptores Purinérgicos P1 / Glioblastoma / Citosina / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Inibidores da Fosfodiesterase 4 / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article