Molecular Determinants of Flavivirus Virion Assembly.
Trends Biochem Sci
; 46(5): 378-390, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33423940
ABSTRACT
Virion assembly is an important step in the life cycle of all viruses. For viruses of the Flavivirus genus, a group of enveloped positive-sense RNA viruses, the assembly step represents one of the least understood processes in the viral life cycle. While assembly is primarily driven by the viral structural proteins, recent studies suggest that several nonstructural proteins also play key roles in coordinating the assembly and packaging of the viral genome. This review focuses on describing recent advances in our understanding of flavivirus virion assembly, including the intermolecular interactions between the viral structural (capsid) and nonstructural proteins (NS2A and NS2B-NS3), host factors, as well as features of the viral genomic RNA required for efficient flavivirus virion assembly.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavivirus
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Canadá