Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories.
Open Biol
; 11(1): 200247, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33435818
ABSTRACT
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although advances are being made towards earlier detection and the development of impactful targeted therapies and immunotherapies, the 5-year survival of patients with advanced disease is still below 20%. Effective cancer research relies on pre-clinical model systems that accurately reflect the evolutionary course of disease progression and mimic patient responses to therapy. Here, we review pre-clinical models, including genetically engineered mouse models and patient-derived materials, such as cell lines, primary cell cultures, explant cultures and xenografts, that are currently being used to interrogate NSCLC evolution from pre-invasive disease through locally invasive cancer to the metastatic colonization of distant organ sites.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
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Modelos Biológicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Open Biol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido