[The role of IL4I1 in immunoregulation: An update].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 37(1): 79-83, 2021 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-33441232
ABSTRACT
Interleukin-4 induced 1 protein (IL4I1), a secreted amino acid oxidase produced by antigen presenting cells, oxidizes phenylalanine to phenylpyruvate. It has been found that IL4I1 exerts an immunosuppressive function by inhibiting the proliferation and differentiation of T cells as well as limiting the proliferation of B cells. IL4I1 is involved in host defense against infection. As a gene related to poor prognosis in cancers, IL4I1 participates in tumor immune escape. IL4I1 promotes remyelination via regulation of the different phenotypes of microglia in the autoimmune demyelinating diseases, but the detailed mechanism still remains unknown. We summarize the role and mechanism of IL4I1 in the immune regulation to provide new ideas for the treatment of infections, cancers and autoimmune diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
L-Aminoácido Oxidase
/
Neoplasias
Limite:
Humans
Idioma:
Zh
Revista:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China