Estimation of the hemoglobin glycation rate constant.

ABSTRACT

In a previous study, a method of obtaining mean erythrocyte age ([Formula see text]) from HbA1c and average plasma glucose (AG) was proposed. However, the true value of the hemoglobin glycation constant ([Formula see text] dL/mg/day), required for this model has yet to be well characterized. Another study also proposed a method of deriving [Formula see text] from erythrocyte creatine (EC). Utilizing these formulae, this study aimed to determine a more accurate estimate of [Formula see text]. One hundred and seven subjects including 31 patients with hemolytic anemia and 76 subjects without anemia were included in this study. EC and HbA1c data were analyzed, and [Formula see text] using HbA1c, AG and the newly-derived constant, [Formula see text] were compared to [Formula see text] using traditional [Formula see text] in three patients whose data were taken from previous case studies. A value of [Formula see text] dL/mg/day was determined for [Formula see text]. [Formula see text] using HbA1c, AG and [Formula see text] were found to no be significantly different (paired t-test, [Formula see text]) to [Formula see text] using traditional [Formula see text]. [Formula see text] enables the estimation of [Formula see text] from HbA1c and AG.