MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice.

Ying, Wei; Gao, Hong; Dos Reis, Felipe Castellani Gomes; Bandyopadhyay, Gautam; Ofrecio, Jachelle M; Luo, Zhenlong; Ji, Yudong; Jin, Zhongmou; Ly, Crystal; Olefsky, Jerrold M

Ying, Wei; Gao, Hong; Dos Reis, Felipe Castellani Gomes; Bandyopadhyay, Gautam; Ofrecio, Jachelle M; Luo, Zhenlong; Ji, Yudong; Jin, Zhongmou; Ly, Crystal; Olefsky, Jerrold M.

Afiliação

Ying W; Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA. Electronic address: weying@health.ucsd.edu.
Gao H; Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Dos Reis FCG; Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Bandyopadhyay G; Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Ofrecio JM; Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Luo Z; Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Ji Y; Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Jin Z; Division of Biological Sciences, University of California, San Diego, San Diego, CA, USA.
Ly C; Division of Biological Sciences, University of California, San Diego, San Diego, CA, USA.
Olefsky JM; Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA. Electronic address: jolefsky@health.ucsd.edu.

Cell Metab ; 33(4): 781-790.e5, 2021 04 06.

Article em En | MEDLINE | ID: mdl-33450179

Assuntos

Exossomos/metabolismo; Macrófagos/metabolismo; MicroRNAs/metabolismo; Adipócitos/citologia; Adipócitos/metabolismo; Animais; Antagomirs/metabolismo; RNA Helicases DEAD-box/deficiência; RNA Helicases DEAD-box/genética; Dieta Hiperlipídica; Hepatócitos/citologia; Hepatócitos/metabolismo; Insulina/metabolismo; Resistência à Insulina; Macrófagos/citologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Obesos; MicroRNAs/antagonistas & inibidores; MicroRNAs/genética; Fibras Musculares Esqueléticas/citologia; Fibras Musculares Esqueléticas/metabolismo; Obesidade/metabolismo; Obesidade/patologia; Fosfotransferases (Aceptor do Grupo Álcool)/antagonistas & inibidores; Fosfotransferases (Aceptor do Grupo Álcool)/genética; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Interferência de RNA; RNA Interferente Pequeno/metabolismo; Ribonuclease III/deficiência; Ribonuclease III/genética

Palavras-chave

exosomes; insulin sensitivity; macrophages; miR-690; obesity

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Exossomos / Macrófagos Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google