gamma-Aminobutyric acid (GABA) and sepsis-related encephalopathy.
Can J Neurol Sci
; 15(1): 23-5, 1988 Feb.
Article
em En
| MEDLINE
| ID: mdl-3345457
ABSTRACT
In order to determine whether disturbances in GABA homeostasis might play a role in the pathogenesis of sepsis-related encephalopathy, serum and brain tissue GABA concentrations from six areas of the brain (cortex, diencephalon, striatum, hippocampus, midbrain, and pons-medulla) were determined in a rat model of bacterial sepsis (cecal ligation and perforation). The results were compared to those obtained from sham operated control animals. All septic animals demonstrated clinical signs of encephalopathy and had elevated serum GABA levels (0.92 +/- 0.3 uM versus 0.48 +/- 0.15 in controls, p less than 0.01). GABA content in the specific subcompartments of the brain, however, were similar in the two groups. These results indicate that although serum GABA levels are elevated during sepsis, GABA is unlikely to play an important role in the pathogenesis of sepsis-related encephalopathy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
/
Encefalopatias
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
En
Revista:
Can J Neurol Sci
Ano de publicação:
1988
Tipo de documento:
Article