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Hepatocellular carcinoma and the risk of de novo malignancies after liver transplantation - a multicenter cohort study.
Shalaby, Sarah; Taborelli, Martina; Zanetto, Alberto; Ferrarese, Alberto; D'Arcangelo, Francesca; Gambato, Martina; Senzolo, Marco; Russo, Francesco Paolo; Germani, Giacomo; Boccagni, Patrizia; Ettorre, Giuseppe Maria; Baccarani, Umberto; Lauro, Augusto; Galatioto, Laura; Rendina, Maria; Petrara, Raffaella; De Rossi, Anita; Nudo, Francesco; Toti, Luca; Fantola, Giovanni; Vennarecci, Giovanni; Risaliti, Andrea; Pinna, Antonio Daniele; Gruttadauria, Salvatore; Di Leo, Alfredo; Rossi, Massimo; Tisone, Giuseppe; Zamboni, Fausto; Cillo, Umberto; Piselli, Pierluca; Serraino, Diego; Burra, Patrizia.
Afiliação
  • Shalaby S; Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • Taborelli M; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
  • Zanetto A; Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • Ferrarese A; Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • D'Arcangelo F; Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • Gambato M; Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • Senzolo M; Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • Russo FP; Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • Germani G; Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • Boccagni P; Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • Ettorre GM; Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy.
  • Baccarani U; Department of Medicine, University of Udine, Udine, Italy.
  • Lauro A; Liver and Multiorgan Transplant Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
  • Galatioto L; Department of Gastroenterology and Hepatology, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center, Palermo, Italy.
  • Rendina M; Department of Emergency and Organ Transplantation, Gastroenterology Section, University Hospital, Bari, Italy.
  • Petrara R; Oncology and Immunology Section, AIDS Reference Center, Department of Oncology and Immunology, University of Padua, Padua, Italy.
  • De Rossi A; Oncology and Immunology Section, AIDS Reference Center, Department of Oncology and Immunology, University of Padua, Padua, Italy.
  • Nudo F; Department of General Surgery and Organ Transplantation, Umberto I Policlinic, Sapienza University, Rome, Italy.
  • Toti L; UOC Transplant Unit, Department of Surgery, Tor Vergata University, Rome, Italy.
  • Fantola G; Department of Surgery, General and Hepatic Transplantation Surgery Unit, A.O.B. Brotzu, Cagliari, Italy.
  • Vennarecci G; Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy.
  • Risaliti A; Department of Medicine, University of Udine, Udine, Italy.
  • Pinna AD; Liver and Multiorgan Transplant Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
  • Gruttadauria S; Department of Gastroenterology and Hepatology, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), University of Pittsburgh Medical Center, Palermo, Italy.
  • Di Leo A; Department of Emergency and Organ Transplantation, Gastroenterology Section, University Hospital, Bari, Italy.
  • Rossi M; Department of General Surgery and Organ Transplantation, Umberto I Policlinic, Sapienza University, Rome, Italy.
  • Tisone G; UOC Transplant Unit, Department of Surgery, Tor Vergata University, Rome, Italy.
  • Zamboni F; Department of Surgery, General and Hepatic Transplantation Surgery Unit, A.O.B. Brotzu, Cagliari, Italy.
  • Cillo U; Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
  • Piselli P; Department of Epidemiology, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy.
  • Serraino D; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
  • Burra P; Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
Transpl Int ; 34(4): 743-753, 2021 04.
Article em En | MEDLINE | ID: mdl-33492715
Patients with hepatocellular carcinoma (HCC) are at high risk of second primary malignancies. As HCC has become the leading indication of liver transplant (LT), the aim of this study was to investigate whether the presence of HCC before LT could influence the onset of de novo malignancies (DNM). A cohort study was conducted on 2653 LT recipients. Hazard ratios (HR) of DNM development for patients transplanted for HCC (HCC patients) were compared with those of patients without any previous malignancy (non-HCC patients). All models were adjusted for sex, age, calendar year at transplant, and liver disease etiology. Throughout 17 903 person-years, 6.6% of HCC patients and 7.4% of non-HCC patients developed DNM (202 cases). The median time from LT to first DNM diagnosis was shorter for solid tumors in HCC patients (2.7 vs 4.5 years for HCC and non-HCC patients, respectively, P < 0.01). HCC patients were at a higher risk of bladder cancer and skin melanoma. There were no differences in cumulative DNM-specific mortality by HCC status. This study suggests that primary HCC could be a risk factor for DNM in LT recipients, allowing for risk stratification and screening individualization.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Transpl Int Assunto da revista: TRANSPLANTE Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Transpl Int Assunto da revista: TRANSPLANTE Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália