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The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway.
Kambey, Piniel Alphayo; Chengcheng, Ma; Xiaoxiao, Guo; Abdulrahman, Ayanlaja Abiola; Kanwore, Kouminin; Nadeem, Iqra; Jiao, Wu; Gao, Dianshuai.
Afiliação
  • Kambey PA; Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
  • Chengcheng M; Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
  • Xiaoxiao G; Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
  • Abdulrahman AA; Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
  • Kanwore K; Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
  • Nadeem I; Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
  • Jiao W; Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
  • Gao D; Xuzhou Key Laboratory of Neurobiology, Department of Neurobiology and Anatomy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. gds@xzhmu.edu.cn.
Metab Brain Dis ; 36(4): 609-625, 2021 04.
Article em En | MEDLINE | ID: mdl-33507465
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Transtornos Parkinsonianos / Proteínas Quinases p38 Ativadas por Mitógeno / Membro 2 do Grupo A da Subfamília 4 de Receptores Nucleares / Amodiaquina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Metab Brain Dis Assunto da revista: CEREBRO / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Transtornos Parkinsonianos / Proteínas Quinases p38 Ativadas por Mitógeno / Membro 2 do Grupo A da Subfamília 4 de Receptores Nucleares / Amodiaquina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Metab Brain Dis Assunto da revista: CEREBRO / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China