Intracranial mast cells contribute to the control of social behavior in male mice.
Behav Brain Res
; 403: 113143, 2021 04 09.
Article
em En
| MEDLINE
| ID: mdl-33516739
ABSTRACT
Mast cells (MCs) exist intracranially and have been reported to affect higher brain functions in rodents. However, the role of MCs in the regulation of emotionality and social behavior is unclear. In the present study, using male mice, we examined the relationship between MCs and social behavior and investigated the underlying mechanisms. Wild-type male mice intraventricularly injected with a degranulator of MCs exhibited a marked increase in a three-chamber sociability test. In addition, removal of MCs in Mast cell-specific Toxin Receptor-mediated Conditional cell Knock out (Mas-TRECK) male mice showed reduced social preference levels in a three-chamber sociability test without other behavioral changes, such as anxiety-like and depression-like behavior. Mas-TRECK male mice also had reduced serotonin content and serotonin receptor expression and increased oxytocin receptor expression in the brain. These results suggested that MCs may contribute to the regulation of social behavior in male mice. This effect may be partially mediated by serotonin derived from MCs in the brain.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Social
/
Comportamento Animal
/
Encéfalo
/
Serotonina
/
Receptores de Serotonina
/
Mastócitos
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão