Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System.

Gava, Fabio N; da Silva, Alexandre A; Dai, Xuemei; Harmancey, Romain; Ashraf, Sadia; Omoto, Ana C M; Salgado, Mateus C; Moak, Sydney P; Li, Xuan; Hall, John E; do Carmo, Jussara M

Gava, Fabio N; da Silva, Alexandre A; Dai, Xuemei; Harmancey, Romain; Ashraf, Sadia; Omoto, Ana C M; Salgado, Mateus C; Moak, Sydney P; Li, Xuan; Hall, John E; do Carmo, Jussara M.

Afiliação

Gava FN; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
da Silva AA; Department of Veterinary Clinics, Londrina State University, Parana, Brazil.
Dai X; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Harmancey R; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Ashraf S; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Omoto ACM; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Salgado MC; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Moak SP; Department of Physiology, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
Li X; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Hall JE; Centro Universitário Barão de Mauá, Ribeirão Preto, São Paulo, Brazil.
do Carmo JM; Department of Physiology and Biophysics and Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.

JACC Basic Transl Sci ; 6(1): 55-70, 2021 Jan.

Article em En | MEDLINE | ID: mdl-33532666

RESUMO

Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors and elicit improvements in cardiac substrate oxidation, cardiomyocyte contractility, Ca2+ coupling, and mitochondrial efficiency. These findings highlight a potentially novel therapeutic approach for myocardial infarction and heart failure.

Palavras-chave

AMPK, adenosine monophosphateactivated protein kinase; BP, blood pressure; CNS, central nervous system; HF, heart failure; HR, heart rate; ICV, intracerebroventricular; LV, left ventricular; MC4R; MC4R, melanocortin-4 receptor; MI, myocardial infarction; MTII, melanotan II; appetite; blood pressure; cardiac metabolism; heart failure; mTOR, mechanistic target of rapamycin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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