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Neutralization of Zika virus by E protein domain III-Specific human monoclonal antibody.
Kim, Sang Il; Kim, Sujeong; Shim, Jung Min; Lee, Hyo Jung; Chang, So Young; Park, Seoryeong; Min, Ji-Young; Park, Wan Beom; Oh, Myoung-Don; Kim, Seungtaek; Chung, Junho.
Afiliação
  • Kim SI; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. Electronic address: sangk1128@snu.ac.kr.
  • Kim S; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea; Department of Biomedical Science, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. Electronic address: sujeong5425@snu.ac.kr.
  • Shim JM; Zoonotic Virus Laboratory, Institut Pasteur Korea, Gyeonggi-do, 13488, Republic of Korea.
  • Lee HJ; Zoonotic Virus Laboratory, Institut Pasteur Korea, Gyeonggi-do, 13488, Republic of Korea. Electronic address: heading1230@naver.com.
  • Chang SY; Respiratory Virus Laboratory, Institut Pasteur Korea, Gyeonggi-do, 13488, Republic of Korea. Electronic address: sychang0709@gmail.com.
  • Park S; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. Electronic address: ryeong0512@gmail.com.
  • Min JY; Respiratory Virus Laboratory, Institut Pasteur Korea, Gyeonggi-do, 13488, Republic of Korea. Electronic address: ji-young.x.min@gsk.com.
  • Park WB; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. Electronic address: wbpark1@snu.ac.kr.
  • Oh MD; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. Electronic address: mdohmd@snu.ac.kr.
  • Kim S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Gyeonggi-do, 13488, Republic of Korea. Electronic address: seungtaek.kim@ip-korea.org.
  • Chung J; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea; Department of Biomedical Science, Seoul National University Col
Biochem Biophys Res Commun ; 545: 33-39, 2021 03 19.
Article em En | MEDLINE | ID: mdl-33535104
ABSTRACT
Zika virus (ZIKV) infection in both infants and adults is associated with neurological complications including, but not limited to, microcephaly and Guillain-Barre syndrome. Antibody therapy can be effective against virus infection. We isolated ZIKV envelope domain III-specific neutralizing antibodies (nAbs) from two convalescent patients with ZIKV infection. One antibody, 2F-8, exhibited potent in vitro neutralizing activity against Asian and American strains of ZIKV. To prevent FcγR-mediated antibody-dependent enhancement, we prepared IgG1 with LALA variation. A single dose of 2F-8 in the context of IgG1 or IgG1-LALA prior to or post lethal ZIKV challenge conferred complete protection in mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Anticorpos Neutralizantes / Zika virus / Anticorpos Monoclonais / Anticorpos Antivirais Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Anticorpos Neutralizantes / Zika virus / Anticorpos Monoclonais / Anticorpos Antivirais Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2021 Tipo de documento: Article