Transcriptome-Guided Design of Physiological Multilineage Liver Organoids.

Zhu, Shijia; Kubota, Naoto; Hoshida, Yujin

Zhu, Shijia; Kubota, Naoto; Hoshida, Yujin.

Afiliação

Zhu S; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kubota N; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hoshida Y; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: Yujin.Hoshida@UTSouthwestern.edu.

Trends Genet ; 37(5): 403-404, 2021 05.

Article em En | MEDLINE | ID: mdl-33541711

ABSTRACT

ABSTRACT

Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.

Assuntos

Células-Tronco Pluripotentes Induzidas; Organoides; Humanos; Fígado; Transcriptoma

Palavras-chave

gene regulatory network; human induced pluripotent stem cell; organogenesis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organoides / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Trends Genet Assunto da revista: GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google