Combined lifestyle factors are associated with the risk of ischaemic stroke in a Chinese population.
Postgrad Med J
; 98(1161): e8, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-33541926
ABSTRACT
PURPOSE:
Lifestyle plays an important role in the development of ischaemic stroke (IS). The objective of this study was to evaluate the association between combined lifestyle factors and the risk of IS in an eastern Chinese population.METHODS:
We collected lifestyle information from 191 patients with IS admitted to the second affiliated hospital of Soochow University and 575 control subjects from community clinics using a structured questionnaire. After division into training and test datasets, regularised stepwise logistic regression, least absolute shrinkage and selection operator regression and genetic algorithm models were used to identify lifestyle factors associated with IS. The improved discriminative ability by adding the lifestyle factors was determined by c-index and reclassification analysis. The final model was validated in the test dataset.RESULTS:
After controlling for conventional cardiovascular disease (CVD) risk factors, preferences for fruits (OR (95% CI) 0.29 (0.18-0.46), p<0.001) and soy products (0.47 (0.29-0.75), p=0.002) were negatively associated with IS, while lower life satisfaction (mildly satisfied 2.15 (1.27-3.63), p=0.004; not satisfied 6.39 (1.76-25.44), p=0.006) was positively associated with IS. Adding these factors to a basic CVD risk model improved the c-index (0.825 vs 0.753, p<0.001) and reclassification for IS (net reclassification index (95% CI) 18.49% (7.90%-29.08%), integrated discrimination index (95% CI) 0.11% (0.08%-0.14%), p<0.001). The model with lifestyle factors achieved a c-index of 0.813 and good calibration in the test dataset.CONCLUSIONS:
Our results showed that combined lifestyle factors including dietary pattern and life satisfaction are independently associated with the risk of IS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Isquemia Encefálica
/
Acidente Vascular Cerebral
/
AVC Isquêmico
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Postgrad Med J
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China