NLRP1: a jack of all trades, or a master of one?

Bachovchin, Daniel A

Bachovchin, Daniel A.

Afiliação

Bachovchin DA; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. Electronic address: bachovcd@mskcc.org.

Mol Cell ; 81(3): 423-425, 2021 02 04.

Article em En | MEDLINE | ID: mdl-33545058

ABSTRACT

ABSTRACT

Recent studies provide evidence that two chemically and mechanistically distinct signals activate the human NLRP1 inflammasome, challenging the concept that it-like other mammalian inflammasomes characterized thus far-evolved to detect and respond to a single danger-associated molecular pattern.

Assuntos

Inflamassomos; Peptídeo Hidrolases; Proteases Virais 3C; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Animais; Proteínas Reguladoras de Apoptose/metabolismo; Cisteína Endopeptidases; Humanos; Inflamassomos/metabolismo; Proteínas NLR; Proteínas Virais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Inflamassomos Limite: Animals / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article

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