Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.

Li, Ying; Yu, Xiao-Jing; Xiao, Tong; Chi, Hong-Li; Zhu, Guo-Qing; Kang, Yu-Ming

Li, Ying; Yu, Xiao-Jing; Xiao, Tong; Chi, Hong-Li; Zhu, Guo-Qing; Kang, Yu-Ming.

Afiliação

Li Y; Key Laboratory of Environment and Genes Related To Diseases of Education Ministry of China, Department of Physiology and Pathophysiology, Shaanxi Engineering and Research Center of Vaccine, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an, 710061, China.
Yu XJ; Key Laboratory of Environment and Genes Related To Diseases of Education Ministry of China, Department of Physiology and Pathophysiology, Shaanxi Engineering and Research Center of Vaccine, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an, 710061, China.
Xiao T; Key Laboratory of Environment and Genes Related To Diseases of Education Ministry of China, Department of Physiology and Pathophysiology, Shaanxi Engineering and Research Center of Vaccine, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an, 710061, China.
Chi HL; Key Laboratory of Environment and Genes Related To Diseases of Education Ministry of China, Department of Physiology and Pathophysiology, Shaanxi Engineering and Research Center of Vaccine, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an, 710061, China.
Zhu GQ; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing, 210029, China.
Kang YM; Key Laboratory of Environment and Genes Related To Diseases of Education Ministry of China, Department of Physiology and Pathophysiology, Shaanxi Engineering and Research Center of Vaccine, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an, 710061, China. ykang@mail.xjtu.edu.cn.

Cardiovasc Toxicol ; 21(6): 472-489, 2021 06.

Article em En | MEDLINE | ID: mdl-33582931

Assuntos

Pressão Sanguínea; Hipertensão Renovascular/metabolismo; Mitocôndrias/metabolismo; Fator 1 Nuclear Respiratório/metabolismo; Estresse Oxidativo; Núcleo Hipotalâmico Paraventricular/metabolismo; Superóxidos/metabolismo; Animais; Modelos Animais de Doenças; Técnicas de Silenciamento de Genes; Hipertensão Renovascular/genética; Hipertensão Renovascular/fisiopatologia; Hipertensão Renovascular/prevenção & controle; Masculino; Mitocôndrias/genética; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/metabolismo; Fator 1 Nuclear Respiratório/genética; Núcleo Hipotalâmico Paraventricular/fisiopatologia; Interferência de RNA; Ratos Sprague-Dawley

Palavras-chave

Hypertension; Hypothalamic paraventricular nucleus (PVN); Mitochondria; Recombinant nuclear respiratory factor 1 (Nrf1); Superoxide; Two-kidney, one-clip (2K1C)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Hipotalâmico Paraventricular / Pressão Sanguínea / Superóxidos / Estresse Oxidativo / Fator 1 Nuclear Respiratório / Hipertensão Renovascular / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cardiovasc Toxicol Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / TOXICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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