The search for a convenient procedure to detect one of the earliest signs of Alzheimer's disease: A systematic review of the prediction of brain amyloid status.
Alzheimers Dement
; 17(5): 866-887, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33583100
ABSTRACT
INTRODUCTION:
Convenient, cost-effective tests for amyloid beta (Aß) are needed to identify those at higher risk for developing Alzheimer's disease (AD). This systematic review evaluates recent models that predict dichotomous Aß. (PROSPERO CRD42020144734).METHODS:
We searched Embase and identified 73 studies from 29,581 for review. We assessed study quality using established tools, extracted information, and reported results narratively.RESULTS:
We identified few high-quality studies due to concerns about Aß determination and analytical issues. The most promising convenient, inexpensive classifiers consist of age, apolipoprotein E genotype, cognitive measures, and/or plasma Aß. Plasma Aß may be sufficient if pre-analytical variables are standardized and scalable assays developed. Some models lowered costs associated with clinical trial recruitment or clinical screening.DISCUSSION:
Conclusions about models are difficult due to study heterogeneity and quality. Promising prediction models used demographic, cognitive/neuropsychological, imaging, and plasma Aß measures. Further studies using standardized Aß determination, and improved model validation are required.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Biomarcadores
/
Valor Preditivo dos Testes
/
Peptídeos beta-Amiloides
/
Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos