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Cholangiocyte organoids can repair bile ducts after transplantation in the human liver.
Sampaziotis, Fotios; Muraro, Daniele; Tysoe, Olivia C; Sawiak, Stephen; Beach, Timothy E; Godfrey, Edmund M; Upponi, Sara S; Brevini, Teresa; Wesley, Brandon T; Garcia-Bernardo, Jose; Mahbubani, Krishnaa; Canu, Giovanni; Gieseck, Richard; Berntsen, Natalie L; Mulcahy, Victoria L; Crick, Keziah; Fear, Corrina; Robinson, Sharayne; Swift, Lisa; Gambardella, Laure; Bargehr, Johannes; Ortmann, Daniel; Brown, Stephanie E; Osnato, Anna; Murphy, Michael P; Corbett, Gareth; Gelson, William T H; Mells, George F; Humphreys, Peter; Davies, Susan E; Amin, Irum; Gibbs, Paul; Sinha, Sanjay; Teichmann, Sarah A; Butler, Andrew J; See, Teik Choon; Melum, Espen; Watson, Christopher J E; Saeb-Parsy, Kourosh; Vallier, Ludovic.
Afiliação
  • Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK. fs347@cam.ac.uk lv225@cam.ac.uk.
  • Muraro D; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Tysoe OC; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • Sawiak S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Beach TE; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Godfrey EM; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
  • Upponi SS; Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Brevini T; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
  • Wesley BT; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • Garcia-Bernardo J; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • Mahbubani K; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Canu G; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Gieseck R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.
  • Berntsen NL; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
  • Mulcahy VL; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Crick K; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Fear C; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Robinson S; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.
  • Swift L; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Gambardella L; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Bargehr J; Academic Department of Medical Genetics, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Ortmann D; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • Brown SE; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • Osnato A; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • Murphy MP; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • Corbett G; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Gelson WTH; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Mells GF; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Humphreys P; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Davies SE; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Amin I; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Gibbs P; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Sinha S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
  • Teichmann SA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Butler AJ; Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • See TC; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Melum E; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • Watson CJE; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
  • Saeb-Parsy K; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
  • Vallier L; Academic Department of Medical Genetics, University of Cambridge, Cambridge, Cambridgeshire, UK.
Science ; 371(6531): 839-846, 2021 02 19.
Article em En | MEDLINE | ID: mdl-33602855
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Ductos Biliares / Ductos Biliares / Ductos Biliares Intra-Hepáticos / Organoides / Células Epiteliais / Terapia Baseada em Transplante de Células e Tecidos Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Ductos Biliares / Ductos Biliares / Ductos Biliares Intra-Hepáticos / Organoides / Células Epiteliais / Terapia Baseada em Transplante de Células e Tecidos Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2021 Tipo de documento: Article