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Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14ß-dihydroxy-6ß-[(4'-pyridyl) carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors.
Huang, Boshi; Gunta, Rama; Wang, Huiqun; Li, Mengchu; Cao, Danni; Mendez, Rolando E; Gillespie, James C; Chen, Chongguang; Huang, Lan-Hsuan M; Liu-Chen, Lee-Yuan; Selley, Dana E; Zhang, Yan.
Afiliação
  • Huang B; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States.
  • Gunta R; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States.
  • Wang H; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States.
  • Li M; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States.
  • Cao D; Center for Substance Abuse Research and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 851, Philadelphia, PA 19140, United States; Beijing Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Toxicology and Medical Countermea
  • Mendez RE; Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA 23298, United States.
  • Gillespie JC; Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA 23298, United States.
  • Chen C; Center for Substance Abuse Research and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 851, Philadelphia, PA 19140, United States.
  • Huang LM; Center for Substance Abuse Research and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 851, Philadelphia, PA 19140, United States.
  • Liu-Chen LY; Center for Substance Abuse Research and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 851, Philadelphia, PA 19140, United States.
  • Selley DE; Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA 23298, United States.
  • Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States. Electronic address: yzhang2@vcu.edu.
Bioorg Chem ; 109: 104702, 2021 04.
Article em En | MEDLINE | ID: mdl-33631465
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Opioides / Morfinanos Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Opioides / Morfinanos Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos