Regulating the immunosuppressive tumor microenvironment to enhance breast cancer immunotherapy using pH-responsive hybrid membrane-coated nanoparticles.

Gong, Chunai; Yu, Xiaoyan; Zhang, Wei; Han, Lu; Wang, Rong; Wang, Yujie; Gao, Shen; Yuan, Yongfang

Gong, Chunai; Yu, Xiaoyan; Zhang, Wei; Han, Lu; Wang, Rong; Wang, Yujie; Gao, Shen; Yuan, Yongfang.

Afiliação

Gong C; Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201999, China.
Yu X; Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201999, China.
Zhang W; Department of Pharmaceutics, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200000, China.
Han L; Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201999, China.
Wang R; Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201999, China.
Wang Y; Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201999, China.
Gao S; Department of Pharmaceutics, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. liullk@126.com.
Yuan Y; Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201999, China. nmxyyf@126.com.

J Nanobiotechnology ; 19(1): 58, 2021 Feb 25.

Article em En | MEDLINE | ID: mdl-33632231

Assuntos

Antineoplásicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Imunossupressores/farmacologia; Imunoterapia/métodos; Nanopartículas/química; Microambiente Tumoral/efeitos dos fármacos; Animais; Apoptose; Antígeno B7-H1; Biomimética; Mama; Neoplasias da Mama/patologia; Ciclo Celular; Linhagem Celular Tumoral; Citocinas; Feminino; Fibrinogênio/genética; Inativação Gênica/efeitos dos fármacos; Humanos; Concentração de Íons de Hidrogênio; Lisossomos; Macrófagos/metabolismo; Metformina; Camundongos; Camundongos Endogâmicos BALB C; Células RAW 264.7; RNA Interferente Pequeno; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Breast cancer; FGL1 siRNA; Hybrid biomimetic membrane; Immunotherapy; Metformin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Nanopartículas / Microambiente Tumoral / Imunossupressores / Imunoterapia / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Nanobiotechnology Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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