The Common Germline <i>TP53-R337H</i> Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model.

Jeffers, John R; Pinto, Emilia M; Rehg, Jerold E; Clay, Michael R; Wang, Jinling; Neale, Geoffrey; Heath, Richard J; Lozano, Guillermina; Lalli, Enzo; Figueiredo, Bonald C; Pappo, Alberto S; Rodriguez-Galindo, Carlos; Chen, Wenan; Pounds, Stanley; Ribeiro, Raul C; Zambetti, Gerard P

The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model.

Jeffers, John R; Pinto, Emilia M; Rehg, Jerold E; Clay, Michael R; Wang, Jinling; Neale, Geoffrey; Heath, Richard J; Lozano, Guillermina; Lalli, Enzo; Figueiredo, Bonald C; Pappo, Alberto S; Rodriguez-Galindo, Carlos; Chen, Wenan; Pounds, Stanley; Ribeiro, Raul C; Zambetti, Gerard P.

Afiliação

Jeffers JR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Pinto EM; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Rehg JE; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Clay MR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Wang J; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Neale G; The Hartwell Center, St. Jude Children's Research Hospital, Memphis, Tennessee.
Heath RJ; Protein Production Center, St. Jude Children's Research Hospital, Memphis, Tennessee.
Lozano G; The University of Texas, MD Anderson Cancer Center, Houston, Texas.
Lalli E; Université Côte d'Azur, Sophia Antipolis, Valbonne, France.
Figueiredo BC; NEOGENEX-CANCER CNRS International Associated Laboratory, Valbonne, France.
Pappo AS; NEOGENEX-CANCER CNRS International Associated Laboratory, Valbonne, France.
Rodriguez-Galindo C; Instituto de Pesquisa Pelé Pequeno Príncipe and Faculdades Pequeno Príncipe, Curitiba, Brazil.
Chen W; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Pounds S; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee.
Ribeiro RC; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee.
Zambetti GP; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee.

Cancer Res ; 81(9): 2442-2456, 2021 05 01.

Article em En | MEDLINE | ID: mdl-33637564

Assuntos

Modelos Animais de Doenças; Células Germinativas/metabolismo; Mutação em Linhagem Germinativa; Síndrome de Li-Fraumeni/genética; Camundongos/genética; Mutação de Sentido Incorreto; Penetrância; Proteína Supressora de Tumor p53/genética; Animais; Brasil/epidemiologia; Células Cultivadas; Feminino; Fibroblastos/metabolismo; Técnicas de Introdução de Genes; Predisposição Genética para Doença; Síndrome de Li-Fraumeni/epidemiologia; Masculino; Camundongos Endogâmicos C57BL; Camundongos Transgênicos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Síndrome de Li-Fraumeni / Mutação em Linhagem Germinativa / Penetrância / Mutação de Sentido Incorreto / Modelos Animais de Doenças / Células Germinativas / Camundongos Tipo de estudo: Prognostic_studies Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Cancer Res Ano de publicação: 2021 Tipo de documento: Article

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