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[Research progress of effect of berberine in treatment of ulcerative colitis based on cell signaling pathway].
Wang, Jia-Jun; Wang, Jian; Li, Yong; Ren, Mi-Hong; Fu, Yin; Yang, Xian-Juan; Wang, Li-Ying.
Afiliação
  • Wang JJ; College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
  • Wang J; College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
  • Li Y; College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
  • Ren MH; College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
  • Fu Y; College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
  • Yang XJ; College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
  • Wang LY; College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
Zhongguo Zhong Yao Za Zhi ; 46(1): 33-40, 2021 Jan.
Article em Zh | MEDLINE | ID: mdl-33645048
Berberine is the main extract of Coptis chinensis, and its anti-inflammatory, antioxidant, antibacterial and immunomodulatory effects have been confirmed by modern studies. Ulcerative colitis(UC) is a chronic, idiopathic inflammatory bowel disease with unknown etiology. Its causes involve genetics, intestinal microecology and mucosal immune system disorders. In this paper, literatures on relevant pathways and mechanism of berberine on ulcerative colitis in recent years were consulted and summarized to provide me-thods and ideas for developing berberine in the treatment of UC and exploring the mechanisms. The results showed that berberine protects the intestinal mucosal barrier, restores the body's normal immune response, and improves oxidative stress by regulating multiple signaling pathways, such as JAK-STAT, NK-κB, PI3 K-AKT, MAPK, Nrf2, ERS, and MLCK-MLC, so as to treat UC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Berberina / Colite Ulcerativa / Colite Limite: Humans Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Assunto da revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Berberina / Colite Ulcerativa / Colite Limite: Humans Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Assunto da revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China