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Matrine-Type Alkaloids from the Seeds of Sophora alopecuroides and Their Potential Anti-inflammatory Activities.
Li, Jian-Chun; Dai, Wei-Feng; Zhou, Xiao-Qiong; Rao, Kai-Rui; Zhang, Zhi-Jun; Liu, Dan; Chen, Xuan-Qin; Li, Rong-Tao; Li, Hong-Mei.
Afiliação
  • Li JC; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
  • Dai WF; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
  • Zhou XQ; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
  • Rao KR; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
  • Zhang ZJ; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
  • Liu D; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
  • Chen XQ; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
  • Li RT; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
  • Li HM; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
Chem Biodivers ; 18(4): e2001066, 2021 Apr.
Article em En | MEDLINE | ID: mdl-33656782
ABSTRACT
Three new matrine-type alkaloids, 8ß-hydroxyoxysophoridine (1), 9ß-hydroxysophoridine (2), 9ß-hydroxyisosophocarpine (3), together with one known analog, 11,12-dehydromatrine (4), were isolated from the seeds of Sophora alopecuroides L. The structures of new compounds were elucidated using extensive spectroscopic techniques including the experimental and calculated ECD data. The anti-inflammatory activities of all the isolates on NO production in RAW 264.7 cells stimulated by lipopolysaccharide were evaluated. Among them, 8ß-hydroxyoxysophoridine (1) showed a significant inhibitory effect with an IC50 value of 18.26 µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sementes / Extratos Vegetais / Sophora / Alcaloides / Anti-Inflamatórios / Óxido Nítrico Limite: Animals Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sementes / Extratos Vegetais / Sophora / Alcaloides / Anti-Inflamatórios / Óxido Nítrico Limite: Animals Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article