Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis.
JHEP Rep
; 3(2): 100230, 2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-33665587
ALD, alcohol-related liver diseases; ALT, alanine aminotransferase; Alc, alcohol; Alcoholic liver disease; BA, bile acids; BHI, brain heart infusion; Bile acid; C57, conventional mice; C57C57, conventional mice transplanted with their own IM; CA, cholic acid; CCL, CC motif chemokine ligands; CDCA, chenodeoxycholic acid; Col1a1, collagen type-I alpha-1 chain; DCA, deoxycholic acid; Dysbiosis; FDR, false-discovery rate; FXR, farnesoid X receptor; Gut-liver axis; IM, intestinal microbiota; Inflammation; KC, Kupffer cells; KO, knockout; Kupffer cells; LCA, lithocholic acid; LDA, linear discriminative analysis; LEfsE, LDA effect size; MCA, muricholic acid; MO, monocytes/macrophages; Microbiome; NFkB, nuclear factor-kappa B; OTU, operational taxonomic unit; PCA, principal component analysis; PCoA, principal coordinate analysis; PICRUSt, phylogenetic investigation of communities by reconstruction of unobserved states; RIN, RNA integrity number; TBA, total bile acids; TG, triglycerides; TGF, transforming growth factor; TIMP1, tissue inhibitor of metalloproteinase 1; TNF, tumour necrosis factor; UDCA, ursodeoxycholic acid; WT, wild-type; WTKO, WT mice transplanted with the IM of TGR5-KO mice; alpha-SMA, alpha-smooth muscle actin; mMMP9, matrix metallopeptidase 9
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
JHEP Rep
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
França