SREBF2 triggers endoplasmic reticulum stress and Bax dysregulation to promote lipopolysaccharide-induced endothelial cell injury.

Dong, Gang; Huang, Xiaoquan; Wu, Ling; Jiang, Siyu; Tan, Qintian; Chen, Shiyao

Dong, Gang; Huang, Xiaoquan; Wu, Ling; Jiang, Siyu; Tan, Qintian; Chen, Shiyao.

Afiliação

Dong G; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Huang X; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wu L; Center of Evidence-Based Medicine, Fudan University, Shanghai, 200032, People's Republic of China.
Jiang S; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Tan Q; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Chen S; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Cell Biol Toxicol ; 38(1): 185-201, 2022 02.

Article em En | MEDLINE | ID: mdl-33677747

Assuntos

Estresse do Retículo Endoplasmático; Lipopolissacarídeos; Células Endoteliais/metabolismo; Endotélio/metabolismo; Humanos; Lipopolissacarídeos/farmacologia; Cirrose Hepática; Proteína de Ligação a Elemento Regulador de Esterol 2; Receptor 4 Toll-Like/genética; Receptor 4 Toll-Like/metabolismo; Proteína X Associada a bcl-2/genética

Palavras-chave

ECs; Injury; LPS; SREBF2; TLR4; UBE2I; miR590-3p

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Estresse do Retículo Endoplasmático Limite: Humans Idioma: En Revista: Cell Biol Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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