Sonic Hedgehog modulates the inflammatory response and improves functional recovery after spinal cord injury in a thoracic contusion-compression model.

Zhang, Hao; Younsi, Alexander; Zheng, Guoli; Tail, Mohamed; Harms, Anna-Kathrin; Roth, Judith; Hatami, Maryam; Skutella, Thomas; Unterberg, Andreas; Zweckberger, Klaus

Zhang, Hao; Younsi, Alexander; Zheng, Guoli; Tail, Mohamed; Harms, Anna-Kathrin; Roth, Judith; Hatami, Maryam; Skutella, Thomas; Unterberg, Andreas; Zweckberger, Klaus.

Afiliação

Zhang H; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Younsi A; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany. alexander.younsi@med.uni-heidelberg.de.
Zheng G; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Tail M; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Harms AK; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Roth J; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Hatami M; Department of Neuroanatomy, Institute for Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120, Heidelberg, Germany.
Skutella T; Department of Neuroanatomy, Institute for Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120, Heidelberg, Germany.
Unterberg A; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Zweckberger K; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.

Eur Spine J ; 30(6): 1509-1520, 2021 06.

Article em En | MEDLINE | ID: mdl-33704579

Assuntos

Contusões; Traumatismos da Medula Espinal; Animais; Proteínas Hedgehog; Ratos; Ratos Sprague-Dawley; Ratos Wistar; Recuperação de Função Fisiológica; Medula Espinal; Traumatismos da Medula Espinal/tratamento farmacológico

Palavras-chave

Functional recovery; Inflammation; Neuroprotection; Sonic Hedgehog; Spinal cord injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Contusões Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur Spine J Assunto da revista: ORTOPEDIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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