Impact of gender on patients hospitalized for SARS-COV-2 infection: A prospective observational study.
J Med Virol
; 93(7): 4597-4602, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33710652
ABSTRACT
Biological sex could affect the natural history of severe acute respiratory syndrome coronavirus 2 infection. We enrolled all COVID-19 patients admitted to two COVID-19 hospitals in Milan in a prospective observational study. The primary outcome was death during the study period and the secondary outcome was critical disease at hospital admission. The association(s) between clinically relevant, noncollinear variables, and the primary outcome was assessed with uni- and multivariable Logistic regression models. A total of 520 patients were hospitalized of whom 349 (67%) were males with a median age 61 (interquartile range 50-72). A higher proportion of males presented critically ill when compared to females (30.1% vs. 18.7%, p < .046). Death occurred in 86 (24.6%) males and 27 (15.8%) females (p = .024). In multivariable analysis age (per 10 years more) (adjusted odds ratio [AOR] 1.83 [95% confidence interval {CI} 1.42-2.35], p < .0001), obesity (AOR 2.17 [95% CI 1.10-4.31], p = .026), critical disease at hospital admission (AOR 6.34 [95% CI 3.50-11.48], p < .0001) were independently associated to higher odds of death whereas gender was not. In conclusion, a higher proportion of males presented critically ill at hospital admission. Age, critical disease at hospital admission, obesity, anemia, D-dimer, estimated glomerular filtration rate, lactate dehydrogenase, and creatine kinase predicted death in hospitalized COVID-19 patients.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Razão de Masculinidade
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Estado Terminal
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COVID-19
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Itália