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The use of respiratory pathogen panel nasal polymerase chain reaction testing in predicting cutaneous enteroviral infections in the pediatric population.
Perez, Victoria A; Melnick, Laura E; Whittier, Susan; Dayan, Peter S; Garzon, Maria C; Morel, Kimberly D; Levin, Laura E; Lauren, Christine T.
Afiliação
  • Perez VA; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
  • Melnick LE; Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.
  • Whittier S; Departments of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
  • Dayan PS; Department of Emergency Medicine, Columbia University Irving Medical Center, New York, NY, USA.
  • Garzon MC; Department of Dermatology, Columbia University Irving Medical Center, New York, NY, USA.
  • Morel KD; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
  • Levin LE; Department of Dermatology, Columbia University Irving Medical Center, New York, NY, USA.
  • Lauren CT; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Pediatr Dermatol ; 38(3): 602-605, 2021 May.
Article em En | MEDLINE | ID: mdl-33724504
BACKGROUND/OBJECTIVE: To characterize the relationship between the presence of enteroviral skin infection, defined as a positive skin polymerase chain reaction (PCR) test, and the nasopharyngeal (NP) respiratory pathogen panel (RPP) PCR test which includes enterovirus/rhinovirus as an analyte. METHODS: A retrospective chart review was performed on 543 subjects, age 18 years or younger, who had enterovirus (EV) skin swabs performed at an academic medical center in New York City between September 2014 and November 2019. Those patients with positive EV skin PCR were considered to have an enteroviral skin infection, and those with a negative EV skin PCR were considered not to have an enteroviral skin infection. Of those 543 children who had EV skin PCR, 170 also had an NP swab RPP performed. These NP swab RPP results were characterized as positive or negative, and if positive, it was noted if the patient was positive or negative for enterovirus/rhinovirus. The positive predictive value (PPV), negative predictive value (NPV), specificity, and sensitivity of a NP swab RPP for enteroviral skin infection were then calculated. RESULTS: An enterovirus/rhinovirus NP swab RPP had a NPV of 95%, PPV of 43%, sensitivity of 90%, and specificity of 62% for cutaneous enterovirus infection. CONCLUSION: The enteroviral skin PCR test is an assay that was validated at this institution. In clinically suspicious cases of EV, a positive NP swab RPP for enterovirus/rhinovirus is a sensitive test. A negative test is highly predictive of not having EV on the skin. Although further data are needed, given that NP swab RPP is readily available, these data may suggest that an NP swab RPP, when appropriately utilized, can support or exclude a clinical diagnosis of cutaneous enterovirus in the pediatric population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enterovirus / Infecções por Enterovirus Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Humans / Infant País/Região como assunto: America do norte Idioma: En Revista: Pediatr Dermatol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enterovirus / Infecções por Enterovirus Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Humans / Infant País/Região como assunto: America do norte Idioma: En Revista: Pediatr Dermatol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos