Structural simplification of evodiamine: Discovery of novel tetrahydro-ß-carboline derivatives as potent antitumor agents.

Ma, Zonglin; Huang, Yahui; Wan, Kun; Zhu, Fugui; Sheng, Chunquan; Chen, Shuqiang; Liu, Dan; Dong, Guoqiang

Ma, Zonglin; Huang, Yahui; Wan, Kun; Zhu, Fugui; Sheng, Chunquan; Chen, Shuqiang; Liu, Dan; Dong, Guoqiang.

Afiliação

Ma Z; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Huang Y; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Wan K; Medical Supplies Center, Chinese PLA General Hospital, Beijing 100039, China.
Zhu F; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Sheng C; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Chen S; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: chenshuq1992@163.com.
Liu D; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. Electronic address: liudan@syphu.edu.cn.
Dong G; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: dgq-81@163.com.

Bioorg Med Chem Lett ; 40: 127954, 2021 05 15.

Article em En | MEDLINE | ID: mdl-33744440

Assuntos

Antineoplásicos/uso terapêutico; Carbolinas/uso terapêutico; Neoplasias/tratamento farmacológico; Inibidores da Topoisomerase I/uso terapêutico; Inibidores da Topoisomerase II/uso terapêutico; Animais; Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Carbolinas/síntese química; Carbolinas/farmacologia; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Células HCT116; Humanos; Masculino; Camundongos Nus; Estrutura Molecular; Estudo de Prova de Conceito; Quinazolinas/química; Relação Estrutura-Atividade; Inibidores da Topoisomerase I/síntese química; Inibidores da Topoisomerase I/farmacologia; Inibidores da Topoisomerase II/síntese química; Inibidores da Topoisomerase II/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Antitumor activity; Evodiamine; Structural simplification; Structureactivity relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbolinas / Inibidores da Topoisomerase I / Inibidores da Topoisomerase II / Neoplasias / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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