High efficacy of onabotulinumtoxinA treatment in patients with comorbid migraine and depression: a meta-analysis.
J Transl Med
; 19(1): 133, 2021 03 31.
Article
em En
| MEDLINE
| ID: mdl-33789668
ABSTRACT
BACKGROUND:
Migraine and depression are highly prevalent and partly overlapping disorders that cause strong limitations in daily life. Patients tend to respond poorly to the therapies available for these diseases. OnabotulinumtoxinA has been proven to be an effective treatment for both migraine and depression. While many studies have addressed the effect of onabotulinumtoxinA in migraine or depression separately, a growing body of evidence suggests beneficial effects also for patients comorbid with migraine and depression. The current meta-analysis systematically investigates to what extent onabotulinumtoxinA is efficient in migraineurs with depression.METHODS:
A systematic literature search was performed based on PubMed, Scopus and Web of Science from the earliest date till October [Formula see text], 2020. Mean, standard deviation (SD) and sample size have been used to evaluate improvement in depressive symptoms and migraine using random-effects empirical Bayes model.RESULTS:
Our search retrieved 259 studies, eight of which met the inclusion criteria. OnabotulinumtoxinA injections administered to patients with both chronic migraine and major depressive disorder led to mean reduction of [Formula see text] points (CI [[Formula see text]], [Formula see text]) in the BDI scale, of [Formula see text] points (CI [[Formula see text]], [Formula see text]) in the BDI-II scale and of [Formula see text] points (CI [[Formula see text]], [Formula see text]) in the PHQ-9 scale, when evaluating depressive symptoms. In the case of the migraine-related symptoms, we found mean reductions of [Formula see text] (CI [[Formula see text]], [Formula see text]) points in the HIT6 scale, [Formula see text] (CI [[Formula see text]], [Formula see text]) in the MIDAS scale, [Formula see text] (CI [[Formula see text]], [Formula see text]) points in the VAS scale and of [Formula see text] (CI [[Formula see text]], [Formula see text]) migraine episodes per month. Comorbid patients showed slightly better improvements in BDI, HIT6 scores and migraine frequency compared to monomorbid patients. The latter group manifested better results in MIDAS and VAS scores.CONCLUSION:
Treatment with onabotulinumtoxinA leads to a significant reduction of disease severity of both chronic migraine and major depressive disorder in patients comorbid with both diseases. Comparative analyses suggest an equivalent strong effect in monomorbid and comorbid patients, with beneficial effects specifically seen for certain migraine features.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Botulínicas Tipo A
/
Transtorno Depressivo Maior
/
Transtornos de Enxaqueca
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
J Transl Med
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Suécia