Clip Chemistry: Diverse (Bio)(macro)molecular and Material Function through Breaking Covalent Bonds.
Chem Rev
; 121(12): 7059-7121, 2021 06 23.
Article
em En
| MEDLINE
| ID: mdl-33823111
ABSTRACT
In the two decades since the introduction of the "click chemistry" concept, the toolbox of "click reactions" has continually expanded, enabling chemists, materials scientists, and biologists to rapidly and selectively build complexity for their applications of interest. Similarly, selective and efficient covalent bond breaking reactions have provided and will continue to provide transformative advances. Here, we review key examples and applications of efficient, selective covalent bond cleavage reactions, which we refer to herein as "clip reactions." The strategic application of clip reactions offers opportunities to tailor the compositions and structures of complex (bio)(macro)molecular systems with exquisite control. Working in concert, click chemistry and clip chemistry offer scientists and engineers powerful methods to address next-generation challenges across the chemical sciences.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Substâncias Macromoleculares
/
Técnicas de Química Sintética
Idioma:
En
Revista:
Chem Rev
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos