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A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.
de Alwis, Ruklanthi; Gan, Esther S; Chen, Shiwei; Leong, Yan Shan; Tan, Hwee Cheng; Zhang, Summer L; Yau, Clement; Low, Jenny G H; Kalimuddin, Shirin; Matsuda, Daiki; Allen, Elizabeth C; Hartman, Paula; Park, Kyoung-Joo Jenny; Alayyoubi, Maher; Bhaskaran, Hari; Dukanovic, Adrian; Bao, Yanjie; Clemente, Brenda; Vega, Jerel; Roberts, Scott; Gonzalez, Jose A; Sablad, Marciano; Yelin, Rodrigo; Taylor, Wendy; Tachikawa, Kiyoshi; Parker, Suezanne; Karmali, Priya; Davis, Jared; Sullivan, Brian M; Sullivan, Sean M; Hughes, Steve G; Chivukula, Pad; Ooi, Eng Eong.
Afiliação
  • de Alwis R; Viral Research and Experimental Medicine Center, SingHealth Duke-NUS Academic Medical Center, Singapore, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
  • Gan ES; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
  • Chen S; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
  • Leong YS; Viral Research and Experimental Medicine Center, SingHealth Duke-NUS Academic Medical Center, Singapore, Singapore.
  • Tan HC; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
  • Zhang SL; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
  • Yau C; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
  • Low JGH; Viral Research and Experimental Medicine Center, SingHealth Duke-NUS Academic Medical Center, Singapore, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; Department of Infectious Disease, Singapore General Hospital, Singapore, Singapore.
  • Kalimuddin S; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; Department of Infectious Disease, Singapore General Hospital, Singapore, Singapore.
  • Matsuda D; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Allen EC; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Hartman P; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Park KJ; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Alayyoubi M; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Bhaskaran H; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Dukanovic A; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Bao Y; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Clemente B; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Vega J; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Roberts S; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Gonzalez JA; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Sablad M; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Yelin R; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Taylor W; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Tachikawa K; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Parker S; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Karmali P; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Davis J; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Sullivan BM; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Sullivan SM; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA. Electronic address: sean@arcturusrx.com.
  • Hughes SG; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Chivukula P; Arcturus Therapeutics, Inc., 10628 Science Center Drive, San Diego, CA 92121, USA.
  • Ooi EE; Viral Research and Experimental Medicine Center, SingHealth Duke-NUS Academic Medical Center, Singapore, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Mol Ther ; 29(6): 1970-1983, 2021 06 02.
Article em En | MEDLINE | ID: mdl-33823303
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Sintéticas / Anticorpos Neutralizantes / Glicoproteína da Espícula de Coronavírus / Vacinas contra COVID-19 / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Sintéticas / Anticorpos Neutralizantes / Glicoproteína da Espícula de Coronavírus / Vacinas contra COVID-19 / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura