Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound.
J Atheroscler Thromb
; 29(4): 492-501, 2022 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-33827997
ABSTRACT
AIM:
H-type hypertension is connected with carotid atherosclerotic plaques and stroke, whereas neovascularization is a dominant contributor to plaque vulnerability. However, the correlation between H-type hypertension and plaque vulnerability remains unclear. This study aims to explore the influence of H-type hypertension on intraplaque neovascularization (IPN).METHODS:
We enrolled 235 patients with carotid plaques into the investigation and classified them into four groups H-type hypertension group, simple hypertension group, isolated hyperhomocysteinemia group, and control group. Contrast-enhanced ultrasound (CEUS) was performed on them and IPN was evaluated using semi-quantitative visual grading grade 1 (no microbubbles or microbubbles limited to the adventitial side and/or shoulder of plaque) and, grade 2 (diffused microbubbles within plaque or microbubbles enter plaque core). To analyze the correlation between H-type hypertension and the degree of plaque enhancement, logistic regression was used.RESULTS:
Compared with those with CEUS grade 1 plaques, those with CEUS grade 2 plaques had higher frequency of ischemic stroke (29.0% vs. 45.1%, Pï¼0.05), hypertension (41.0% vs. 56.3%, Pï¼0.05), and H-type hypertension (18.0% vs. 29.6%, Pï¼0.05). No significant differences existed in plaque morphology, plaque echogenicity, and the severity of carotid artery stenosis between the degree of plaque enhancement (all Pï¼0.05). H-type hypertension (multivariate-adjusted OR 3.036, 95% CI 1.258-7.329) was independently connected with the degree of plaque enhancement even after adjusting for other covariates.CONCLUSION:
H-type hypertension is expressly connected with the degree of plaque enhancement and may facilitate plaque vulnerability. Our findings may offer a new insight for treating vulnerable plaque, lowering blood pressure, and lowering homocysteine equally crucial.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estenose das Carótidas
/
Placa Aterosclerótica
/
Hipertensão
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Atheroscler Thromb
Assunto da revista:
ANGIOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article