Successful Bone Marrow Transplantation With Intensive Post-transplant Intrathecal Chemotherapy for CNS Relapsed AML in 2 Infants.
J Pediatr Hematol Oncol
; 44(1): e264-e267, 2022 01 01.
Article
em En
| MEDLINE
| ID: mdl-33843815
ABSTRACT
BACKGROUND:
Infant acute myeloid leukemia is a rare but aggressive form of leukemia. OBSERVATION We report 2 children who presented with hyperleukocytosis, subsequently diagnosed with infant acute myeloid leukemia, and both developed isolated central nervous system relapse while on chemotherapy. Both infants underwent successful bone marrow transplantation with myeloablative conditioning (thiotepa, busulfan, and cyclophosphamide) without radiation, followed by 12 empiric post-transplant lumbar punctures with intrathecal cytarabine. Both patients tolerated these therapies well, and are without infections, chronic graft-versus-host disease, or any post-transplant sequelae.CONCLUSION:
Nonradiation-based conditioning followed by empiric central nervous system-directed intrathecal chemotherapy may be considered for high-risk infants with leukemia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
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Transplante de Medula Óssea
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Neoplasias do Sistema Nervoso Central
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Condicionamento Pré-Transplante
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Agonistas Mieloablativos
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Citarabina
Limite:
Female
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Humans
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Infant
Idioma:
En
Revista:
J Pediatr Hematol Oncol
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Ano de publicação:
2022
Tipo de documento:
Article