Tumor DDR1 deficiency reduces liver metastasis by colon carcinoma and impairs stromal reaction.

Romayor, Irene; Márquez, Joana; Benedicto, Aitor; Herrero, Alba; Arteta, Beatriz; Olaso, Elvira

Romayor, Irene; Márquez, Joana; Benedicto, Aitor; Herrero, Alba; Arteta, Beatriz; Olaso, Elvira.

Afiliação

Romayor I; Tumor Microenvironment Group, Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.
Márquez J; Tumor Microenvironment Group, Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.
Benedicto A; Tumor Microenvironment Group, Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.
Herrero A; Tumor Microenvironment Group, Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.
Arteta B; Tumor Microenvironment Group, Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.
Olaso E; Tumor Microenvironment Group, Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.

Am J Physiol Gastrointest Liver Physiol ; 320(6): G1002-G1013, 2021 06 01.

Article em En | MEDLINE | ID: mdl-33851541

ABSTRACT

ABSTRACT

Tumor DDR1 acts as a key factor during the desmoplastic response surrounding hepatic colorectal metastasis. Hepatic sinusoidal cell-derived soluble factors stimulate tumor DDR1 activation. DDR1 modulates matrix remodeling to promote metastasis in the liver through the interaction with hepatic stromal cells, specifically liver sinusoidal endothelial cells and hepatic stellate cells.

Assuntos

Carcinoma/genética; Neoplasias do Colo/genética; Receptor com Domínio Discoidina 1/genética; Neoplasias Hepáticas/genética; Fígado/patologia; Animais; Carcinoma/metabolismo; Carcinoma/secundário; Linhagem Celular Tumoral; Proliferação de Células; Colo/metabolismo; Colo/patologia; Neoplasias do Colo/metabolismo; Neoplasias do Colo/patologia; Receptor com Domínio Discoidina 1/metabolismo; Células Estreladas do Fígado/patologia; Humanos; Fígado/metabolismo; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/secundário; Masculino; Camundongos; Fosforilação; Prognóstico; Células Estromais/metabolismo; Células Estromais/patologia

Palavras-chave

desmoplasia; discoidin domain receptor 1; hepatic stellate cells; liver metastasis from colorectal cancer; liver sinusoidal endothelial cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Neoplasias do Colo / Receptor com Domínio Discoidina 1 / Fígado / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Am J Physiol Gastrointest Liver Physiol Assunto da revista: FISIOLOGIA / GASTROENTEROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Espanha

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