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Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology.
Strub, Thomas; Martel, Arnaud; Nahon-Esteve, Sacha; Baillif, Stéphanie; Ballotti, Robert; Bertolotto, Corine.
Afiliação
  • Strub T; University Côte d'Azur, France; Inserm, Biology and Pathologies of Melanocytes, Team1, Equipe Labellisée Ligue 2020 and Equipe Labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.
  • Martel A; University Côte d'Azur, France; Centre Hospitalier Universitaire de Nice, Department of Ophthalmology, Nice, France.
  • Nahon-Esteve S; University Côte d'Azur, France; Centre Hospitalier Universitaire de Nice, Department of Ophthalmology, Nice, France.
  • Baillif S; University Côte d'Azur, France; Centre Hospitalier Universitaire de Nice, Department of Ophthalmology, Nice, France.
  • Ballotti R; University Côte d'Azur, France; Inserm, Biology and Pathologies of Melanocytes, Team1, Equipe Labellisée Ligue 2020 and Equipe Labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.
  • Bertolotto C; University Côte d'Azur, France; Inserm, Biology and Pathologies of Melanocytes, Team1, Equipe Labellisée Ligue 2020 and Equipe Labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France. Electronic address: corine.bertolotto@univ-cotedazur.fr.
Prog Retin Eye Res ; 85: 100968, 2021 11.
Article em En | MEDLINE | ID: mdl-33852963
Uveal melanoma (UM) is an aggressive and deadly neoplasm. In recent decades, great efforts have been made to obtain a more comprehensive understanding of genetics, genomics and molecular changes in UM, enabling the identification of key cellular processes and signalling pathways. Still, there is no effective treatment for the metastatic disease. Intratumoural heterogeneity (ITH) is thought to be one of the leading determinants of metastasis, therapeutic resistance and recurrence. Crucially, tumours are complex ecosystems, where cancer cells, and diverse cell types from their microenvironment engage in dynamic spatiotemporal crosstalk that allows cancer progression, adaptation and evolution. This highlights the urgent need to gain insight into ITH in UM and its intersection with the microenvironment to overcome treatment failure. Here we provide an overview of the studies and technologies to study ITH in human UMs and tumour micro-environmental composition. We discuss how to incorporate ITH into clinical consideration for the purpose of advocating for new clinical management. We focus on the application of single-cell transcriptomic analysis and propose that understanding the driving forces and functional consequences of the observed tumour heterogeneity holds promise for changing the treatment paradigm of metastatic UMs, surmounting resistance and improving patient prognosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcriptoma / Melanoma Limite: Humans Idioma: En Revista: Prog Retin Eye Res Assunto da revista: OFTALMOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcriptoma / Melanoma Limite: Humans Idioma: En Revista: Prog Retin Eye Res Assunto da revista: OFTALMOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França