Hydropathicity-based prediction of pain-causing NaV1.7 variants.

Xenakis, Makros N; Kapetis, Dimos; Yang, Yang; Gerrits, Monique M; Heijman, Jordi; Waxman, Stephen G; Lauria, Giuseppe; Faber, Catharina G; Westra, Ronald L; Lindsey, Patrick J; Smeets, Hubert J

Xenakis, Makros N; Kapetis, Dimos; Yang, Yang; Gerrits, Monique M; Heijman, Jordi; Waxman, Stephen G; Lauria, Giuseppe; Faber, Catharina G; Westra, Ronald L; Lindsey, Patrick J; Smeets, Hubert J.

Afiliação

Xenakis MN; Department of Toxicogenomics, Section Clinical Genomics, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands. mrksxenakis@gmail.com.
Kapetis D; Research School for Mental Health and Neuroscience (MHeNS), Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands. mrksxenakis@gmail.com.
Yang Y; Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria 11, 20133, Milan, Italy.
Gerrits MM; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, IN, 47907, USA.
Heijman J; Purdue Institute for Integrative Neuroscience, West Lafayette, IN, 47907, USA.
Waxman SG; Department of Clinical Genetics, Maastricht University Medical Center, PO box 5800, 6202 AZ, Maastricht, The Netherlands.
Lauria G; Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Faber CG; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, 06510, USA.
Westra RL; Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, 06516, USA.
Lindsey PJ; Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria 11, 20133, Milan, Italy.
Smeets HJ; Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Via G.B. Grassi 74, 20157, Milan, Italy.

BMC Bioinformatics ; 22(1): 212, 2021 Apr 23.

Article em En | MEDLINE | ID: mdl-33892629

Assuntos

Dor; Humanos; Mutação; Fenótipo

Palavras-chave

Atomic hydropathicity; Computational modeling; Cumulative hydropathic topology; Missense mutations; NaV1.7; Pain; Pathogenicity prediction; Scaling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMC Bioinformatics Assunto da revista: INFORMATICA MEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda

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