Heterogeneities in Cell Cycle Checkpoint Activation Following Doxorubicin Treatment Reveal Targetable Vulnerabilities in <i>TP53</i> Mutated Ultra High-Risk Neuroblastoma Cell Lines.

Ödborn Jönsson, Linnéa; Sahi, Maryam; Lopez-Lorenzo, Ximena; Keller, Faye Leilah; Kostopoulou, Ourania N; Herold, Nikolas; Ährlund-Richter, Lars; Shirazi Fard, Shahrzad

Heterogeneities in Cell Cycle Checkpoint Activation Following Doxorubicin Treatment Reveal Targetable Vulnerabilities in TP53 Mutated Ultra High-Risk Neuroblastoma Cell Lines.

Ödborn Jönsson, Linnéa; Sahi, Maryam; Lopez-Lorenzo, Ximena; Keller, Faye Leilah; Kostopoulou, Ourania N; Herold, Nikolas; Ährlund-Richter, Lars; Shirazi Fard, Shahrzad.

Afiliação

Ödborn Jönsson L; Department of Women's and Children's Health, Karolinska Institutet, 171 64 Stockholm, Sweden.
Sahi M; Department of Women's and Children's Health, Karolinska Institutet, 171 64 Stockholm, Sweden.
Lopez-Lorenzo X; Department of Women's and Children's Health, Karolinska Institutet, 171 64 Stockholm, Sweden.
Keller FL; Department of Women's and Children's Health, Karolinska Institutet, 171 64 Stockholm, Sweden.
Kostopoulou ON; Department of Oncology-Pathology, Karolinska Institutet, 171 64 Stockholm, Sweden.
Herold N; Department of Women's and Children's Health, Karolinska Institutet, 171 64 Stockholm, Sweden.
Ährlund-Richter L; Pediatric Oncology, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, 171 64 Stockholm, Sweden.
Shirazi Fard S; Department of Women's and Children's Health, Karolinska Institutet, 171 64 Stockholm, Sweden.

Int J Mol Sci ; 22(7)2021 Apr 01.

Article em En | MEDLINE | ID: mdl-33915913

Assuntos

Antibióticos Antineoplásicos/uso terapêutico; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Doxorrubicina/uso terapêutico; Neuroblastoma/tratamento farmacológico; Antibióticos Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Doxorrubicina/farmacologia; Genes p53; Humanos; Terapia de Alvo Molecular; Neuroblastoma/genética

Palavras-chave

ATM; DNA damage; cell cycle arrest; drug-resistance; high-risk neuroblastoma; mitotic-arrest; p21; proliferation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doxorrubicina / Pontos de Checagem do Ciclo Celular / Antibióticos Antineoplásicos / Neuroblastoma Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suécia

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