PINK1/Parkin-mediated mitophagy inhibits warangalone-induced mitochondrial apoptosis in breast cancer cells.

Mao, Lianzhi; Liu, Huahuan; Zhang, Rongjun; Deng, Yudi; Hao, Yuting; Liao, Wenzhen; Yuan, Miaomiao; Sun, Suxia

Mao, Lianzhi; Liu, Huahuan; Zhang, Rongjun; Deng, Yudi; Hao, Yuting; Liao, Wenzhen; Yuan, Miaomiao; Sun, Suxia.

Afiliação

Mao L; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Liu H; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Zhang R; Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China.
Deng Y; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Hao Y; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Liao W; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Yuan M; The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518033, Guangdong, China.
Sun S; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.

Aging (Albany NY) ; 13(9): 12955-12972, 2021 04 30.

Article em En | MEDLINE | ID: mdl-33929971

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Autofagia/efeitos dos fármacos; Neoplasias da Mama/tratamento farmacológico; Isoflavonas/farmacologia; Mitofagia/efeitos dos fármacos; Adenina/análogos & derivados; Adenina/farmacologia; Adenina/uso terapêutico; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Apoptose/efeitos dos fármacos; Apoptose/genética; Autofagia/genética; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Cloroquina/farmacologia; Cloroquina/uso terapêutico; Ensaios de Seleção de Medicamentos Antitumorais; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Isoflavonas/uso terapêutico; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Potencial da Membrana Mitocondrial/genética; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/patologia; Mitofagia/genética; Proteínas Quinases/genética; Proteínas Quinases/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

PINK1/Parkin; apoptosis; breast cancer; mitophagy; warangalone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias da Mama / Protocolos de Quimioterapia Combinada Antineoplásica / Mitofagia / Isoflavonas Limite: Female / Humans Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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